Shahid ullah
Shenzhen University, China
Title: Computer aided screening of mangrove ecosystem derived compound against acetyl-cholinesterase
Biography
Biography: Shahid ullah
Abstract
Alzheimer’s disease (AD) is considered as the most common type of dementia among older people. Almost 9 million
people are suff ering from AD in china and increasing with the course of time. Currently many diff erent herbs are used
for the treatment of AD including six Flavors Rehmannia Pills , Gastrodia and Uncaria Drink. It is been suggested that some
Acetyl-cholinesterase inhibitors induced molecular and cellular change that directly infl uence AD pathogeneses. In our study
literature search was perform to fi nd Mangrove eco-system phytochemical structures by using Builder soft ware implemented
in Molecular operating environment (MOE 2009). Acetyl-cholinesterase (PDB ID 1EVE) structure with bound ligand was
retrieved from protein data bank. Molecular docking was performed by triangular matcher placement method and rescore
by London dG parameter. Th e crystal structure has bound ligand which was active against acetyl-cholinesterase. It can be
concluded by docking analysis of diff erent compounds that mangrove ecosystem compound may serve as good inhibitors
against Acetyl-cholinesterase