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Albert Jeltsch

University Stuttgart, Germany

Title: Molecular enzymology of DNA methyltransferases – conformational changes and allosteric regulation

Biography

Biography: Albert Jeltsch

Abstract

DNA methylation is an essential epigenetic chromatin modifi cation. Th e setup and maintenance of DNA methylation patterns
depends on the coordinated activity of DNA methyltransferases (DNMTs) and their allosteric regulation by interacting proteins,
other chromatin modifi cations and post-translational modifi cations. I will present novel assays for DNMTs including single enzyme
assays to study their mechanism and conformationally locked mutants to study allosteric eff ects. Based on this, recent data regarding
the regulation and targeting of DNMTs by allosteric eff ect will be presented. Moreover, I will present insights into the mechanism of
DNMTs regarding target site location, specifi city and processivity.