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N.M. Permyakova

Institute of Macromolecular Chemistry, NAS of Ukraine, Ukraine

Title: Effective biologically active additives for animals based on compositions of α-tocopheryl acetate with micellar nanocarriers

Biography

Biography: N.M. Permyakova

Abstract

Encapsulation of biologically active substances, such as vitamins and antioxidants, into hydrophilic, biocompatible, and biodegradable nanocarriers is one of the possibilities for creating effective food additives for humans and animals. At the same time, the encapsulation processes make it possible to protect active agents from oxidation and rapid elimination from the body, thereby increasing their effectiveness. Current work is devoted to the development and research of non-toxic micellar nanocarriers based on diblock and triblock copolymers (DBCs and TBCs) with biocompatible and biodegradable polyethylene oxide and poly(acrylic acid) blocks for encapsulation and delivery of poorly soluble vitamin E and its analogs, in particular, α-tocopheryl acetate (α-TOCA), in animal organisms. DBCs and TBCs are intramolecular polycomplexes that form special micellar structures of the "cut" and "hairy" types with a complex "core" in aqueous solutions at pH <5. The special structure of DBC and TBC micelles, in particular, the ability of the complex “core” stabilized by a system of hydrogen bonds to self-adjust during drug encapsulation, pH-sensitivity of micelles turned out to be very effective for encapsulation of poorly soluble vitamin E and its analogs (Figure 1). The obtained compositions of -tocopheryl acetate with both types of micellar carriers showed high stability over time in a wide range of pH=3.5-9.0 and in physiological solution. However, in the case of “hairy” micelles, the developed “corona” of longer unbound segments of the polyacrylic acid block provided more reliable protection of the encapsulated drug molecules from the “salting out” effect. The composition of -tocopheryl acetate with given nanocarrier was tested in vivo on a group of sows as a dietary supplement. The positive effect of the micellar form of the drug on metabolic processes in sows, as well as on increasing the productivity of sows, stress resistance and safety of born piglets has been established.