Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer

Back

20th Global Congress on Biotechnology

London, UK

David Rabuka


David Rabuka

Catalent Biologics, USA

Biography

We have developed the SMARTagTM technology platform, which enables precise, programmable, site-selective chemical
protein modifi cation. Leveraging the target sequence of formylglycine generating enzyme (FGE), we chemoenzymatically
modify proteins to generate a precisely placed aldehyde functionality that can be chemically elaborated. Subsequently, novel
ligation chemistry is employed that exploits this “aldehyde tag” site. We will present recent data on our novel protein modifi cation
platform and its application to generating novel bioconjugates, including ADCs, utilizing our new conjugation chemistries and
linkers. Th e application of these chemistries to generate site-specifi cally modifi ed bioconjugates with improved effi cacy and
safety profi les will be presented. Additionally, we will highlight the progress in developing conjugates with a focus on preclinical
studies as well as highlight our progress in cell line development and manufacturing by using this chemoenzymatic approach.

Abstract

Abstract : Developing site-specifi cally modifi ed ADCs using a chemoenzymatic approach